Michael Ladomery, PhD

The main focus of Michael’s research is on alternative splicing. Alternative splicing is the main process through which genes can express multiple protein isoforms. Over 95% of human protein-coding genes are alternatively spliced and it is estimated that one in six of all disease-associated mutations in humans affect alternative splicing.

Current research projects include:

• Targeting the SR splice factor protein kinases SRPK1 and CLK1 in cancer
• Development of morpholino-based antisense oligonucleotides that target oncofetal transcripts
• Function of Chlamydomonas reinhardtii RNA-binding protein CrGRP1 in stress adaptation

Past projects include:

The role of the ERG oncogene and its splice isoforms in prostate cancer

• Development of morpholino-based splice-switching antisense oligonucleotides that target the ERG oncogene
• Regulation of alternative splicing of VEGF, HER2, ERG, and the Insulin Receptor
• Cellular adaptation to hypoxia through regulated alternative splicing

Michael has authored the textbook: The Molecular Biology of RNA. Elliott and Ladomery. First edition published in 2011, Oxford University Press. Second edition published in 2016. He has published 80+ peer reviewed papers in the RNA biology field; H-index 33.