Michael Ladomery

Michael Ladomery is an RNA biologist, a growing area of research that includes pre-mRNA processing, alternative splicing, mRNA export, mRNA translation and localisation, mRNA stability, and the role of noncodingRNAs in regulating gene expression

Speciality RNA Biologist
Degrees PhD Molecular biology
Areas of Expertise
  • RNA Biology
  • Alternative Splicing
  • Translation/Localisation


The main focus of Michael’s research is on alternative splicing. Alternative splicing is the main process through which genes can express multiple protein isoforms. Over 95% of human protein-coding genes are alternatively spliced and it is estimated that one in six of all disease-associated mutations in humans affect alternative splicing.

Current research projects include:

  • Targeting the SR splice factor protein kinases SRPK1 and CLK1 in cancer
  • Development of morpholino-based antisense oligonucleotides that target oncofetal transcripts
  • Function of Chlamydomonas reinhardtii RNA-binding protein CrGRP1 in stress adaptation

Past projects include:

The role of the ERG oncogene and its splice isoforms in prostate cancer

  • Development of morpholino-based splice-switching antisense oligonucleotides that target the ERG oncogene
  • Regulation of alternative splicing of VEGF, HER2, ERG, and the Insulin Receptor
  • Cellular adaptation to hypoxia through regulated alternative splicing

Michael has authored the textbook: The Molecular Biology of RNA. Elliott and Ladomery. First edition published in 2011, Oxford University Press. Second edition published in 2016. He has published 80+ peer reviewed papers in the RNA biology field; H-index 33.

Key Accomplishments

Associate ProfessorUniversity of the West of England, Bristol, UK

Senior LecturerUniversity of the West of England, Bristol, UK

Senior Research AssociateMRC Human Genetics Unit, Scotland,UK

Research AssociateUniversity of St Andrews, Scotland,UK